ea0035oc2.3 | Adrenal clinical | ECE2014
Assie Guillaume
, Jouinot Anne
, Libe Rossella
, Barreau Olivia
, Papathomas Thomas
, Hamzaoui Nadim
, Sbiera Silviu
, Ronchi Christina
, Kroiss Matthias
, Waldmann Jens
, Quinkler Marcus
, Beuschlein Felix
, Mannelli Massimo
, Luconi Michaela
, Mantero Franco
, Groussin Lionel
, Baudin Eric
, de Krijger Ronald
, Fassnacht Martin
, Bertherat Jerome
Background: The prognosis of adrenocortical carcinomas (ACCs) is heterogeneous. Genome-wide methylation analysis of tumor DNA identified a sub-group of ACCs from the French COMETE network with CpG island hypermethylation evoking a CpG island methylator phenotype (CIMP). These ACCs are associated with a poorer prognosis (Barreau, JCEM 2013).The aim was to validate the prognostic value of CIMP in a large multicentric independent cohort from ENSAT (European...